Evaluating the peripheral nervous system pathology of Alzheimer’s disease utilizing a functional human NMJ microphysiological system

Akhmetzada Kargazhanov1, Romy Aiken1, Kenneth Hawkins1, Rafael Lopez1, Ahmad Nawaz1, Gaurav Srivastava1, Chase Miller2, Will Bogen2, Christopher Long2, David Morgan3, Xiufang Guo1, James Hickman1,2.

Affiliations:

  1. Hybrid Systems Lab, NanoScience Technology Center, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.
  2. Hesperos Inc., 12501 Research Pkwy, Suite 100, Orlando, FL 32826, USA.
  3. Department of Translational Neuroscience, Michigan State University College of Human Medicine, 400 Monroe Ave NW, Grand Rapids, MI 49503.
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Evaluating the peripheral nervous system pathology of Alzheimer’s disease utilizing a functional human NMJ microphysiological system

Evaluating the peripheral nervous system pathology of Alzheimer’s disease utilizing a functional human NMJ microphysiological system Akhmetzada Kargazhanov1, Romy Aiken1, Kenneth Hawkins1, Rafael Lopez1, Ahmad Nawaz1, Gaurav Srivastava1, Chase Miller2, Will Bogen2, Christopher Long2, David Morgan3, … Read More

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INTRODUCTION:

Alzheimer’s Disease (AD) is a central nervous system (CNS) neurodegenerative disease leading to dementia, but can also show symptoms of motor deficits. It is not clear whether the peripheral motor deficits in AD are derived from upstream centers or intrinsic to the neuromuscular circuit. This study developed a model to evaluate the neuromuscular pathology of familial AD (fAD) in a functional neuromuscular junction (NMJ) system.