The Original Human-on-a-Chip Company

Pioneers for Reducing Animal Testing through Emulating Biology

the leading light for human-on-a-chip Research

Hesperos is named for Venus in the evening sky. Like her, we are a leading light, providing world-class research in disease modeling and drug testing through our use of human-on-a-chip systems. Our patent positions and the over 20 years of expertise of both Drs. Shuler and Hickman make us the company to work with for your most difficult problems as well as for cost competitive, routine, human-on-a-chip assays.

The hesperos difference

Hesperos, Inc. brings together biologists, surface chemists, and engineers in order to produce some of the worlds most advanced organs-on-chips. From gene expression to electrophysiology, our biologists recreate key components of various organs. Chemically patterned microchips are engineered to enable real-time monitoring of organ activity. Finally, our engineers utilize sophisticated measurement techniques in order to detect and quantify minute changes.  The result of this collaboration is an ability to study therapeutics in a way which was previously only possible in clinical trials.

As Featured In

Industries We Serve

Rare Disease

Pharmacology

Chemicals, Nutraceuticals, and Supplements

Latest News

Dr. Hickman’s Presentation at AAPS about Human-On-A-Chip® technology

By Hesperos | November 20, 2020

Human-on-a-chip System for Use in Therapeutic Index Determination and Systemic Toxicity in Pre-clinical Drug Discovery Presented at AAPS 2020 by James J. Hickman, PhD Chief Scientist, Hesperos, Inc.

future tech Podcast interview with JAMES HICKMAN, PHD, Human-Based Models for Drug Testing

By Hesperos | November 19, 2020

THE SCIENCE AND TECHNOLOGY PLATFORM THAT COULD

Dr. Hickman Presents Human-on-a-Chip® at Florida Simulation Summit 2020

By Hesperos | November 9, 2020

Hesperos Chief Scientist, Dr. James Hickman discusses how a Human-on-a-Chip works at the Florida Simulation Summit 2020

Hesperos listed among 2021 Top Tech Startups in Orlando

By Hesperos | October 15, 2020

The Tech Tribune, the journalistic arm of Crunchbase, recently selected Hesperos as one of the top 10 technology startups in Orlando. We are proud to be listed among the best companies in the City Beautiful. Award … Read More

ALS skeletal muscle for a pathologic role

By Hesperos | September 9, 2020

Unraveling the pathologic role of skeletal muscle in ALS A key challenge in developing effective therapies for amyotrophic lateral sclerosis has been a poor understanding of the disease pathology. To address this issue, a team of … Read More

ALS pathology investigated by UCF/Hesperos Researchers Utilizing a Human-on-a-Chip® model

By Hesperos | August 12, 2020

UCF/HESPEROS RESEARCHERS UTILIZE HUMAN-ON-A-CHIP® APPROACH TO MODEL ALS PATHOLOGY Key Findings Data supports use of functional neuromuscular junction (NMJ) system to evaluate amyotrophic lateral sclerosis pathology  First study to validate the use of Deanna protocol in … Read More

Hesperos demonstrates innovative Human-on-a-Chip® approach to modeling innate immune system response following tissue damage and acute inflammation

By Hesperos | June 2, 2020

— New publication in Advanced Science validates potential use in evaluating certain immune responses in drug discovery and systemic diseases, including Coronavirus Disease 2019 (COVID-19)— — Hesperos’ immune system-on-a-chip features recirculating immune cells with the key … Read More

PRECLINICAL STAGES OF ALZHEIMER’S DISEASE AND MILD COGNITIVE IMPAIRMENT MODELED WITH HESPEROS HUMAN-ON-A-CHIP® SYSTEM

By Hesperos | May 28, 2020

PRECLINICAL STAGES OF ALZHEIMER’S DISEASE AND MILD COGNITIVE IMPAIRMENT MODELED WITH HESPEROS HUMAN-ON-A-CHIP® SYSTEM — Peer-reviewed publication in Alzheimer’s & Dementia: Translational Research & Clinical Interventions validates potential of drug discovery platform and ability to study … Read More

Human-on-a-chip for Rare Diseases discussion

By Hesperos | November 30, 2019

HUMAN-ON-A-CHIP FOR RARE DISEASES DISCUSSION In our latest publication, UCF & Hesperos researchers discuss how Human-on-a-chip systems can be used to address the unique challenges facing rare diseases. Researchers cite that rare diseases are “limited by … Read More

NIH Director Features HESPEROS BODY-ON-A-CHIP DEVICE for predicting CANCER DRUG RESPONSES

By Hesperos | September 30, 2019

Dr. Francis Collins, director of The National Institutes of Health, recently featured Hesperos technology on his blog. In the post, Dr. Collins reviews a published study where Hesperos researchers investigated and treated several cancer lines with … Read More

About Our Team

Hesperos, Inc, is a leader in efforts to characterize an individual’s biology with human-on-a-chip microfluidic systems. Founders Michael L. Shuler and James J. Hickman have been at the forefront of every major scientific discovery in this realm, from individual organ-on-a-chip constructs to fully functional, interconnected multi-organ systems which they coined "human-on-a-chip."

Simulating Organ Function

Unlike other tests that extrapolate organ function based on biomarker activity and protein analysis, our models are working systems that recreate muscle and tissue function as well as neural and inter-organ communication. The resulting functional reports closely correlate to what clinicians observe in human clinical trials.

Data Driven Analysis

Our systems generate thousands of data points which correlate to key functional aspects of each organ.  Our custom analyses are then able to parse the data quickly and fruitfully to identify subtle changes in function alongside large-scale shifts in morphology and behavior, yielding insights into each drug.

Interested in working with hesperos?