About You 

• You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
• You are conscientious and pay almost obsessive attention to detail, as organized documentation is  second nature. 
• You are curious, love learning and are eager to take on hard problems. 
• You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
• You are resourceful and like to work independently but are not shy to ask for advice. 

What You’ll Do 

• Keep detailed and organized records of experimental protocols and results 
• Design, optimize and oversee day to day experiments 
• Analyze and document data, communicate results clearly and concisely to supervisor and peers 
• Compile and interpret data and prepare presentations for management review 
• Assign tasks to and mentor junior scientists (research associates and research assistants) 
• Manage multiple projects (2-4) simultaneously ensuring each project meets required deliverables in  appropriate deadline 
• Develop statement of work (SOW) and standard operating procedures (SOPs) for client contracts
• Present data in client meetings 
• Establish and oversee quality control in all aspects of your team projects 
• Write and submit final reports and manuscripts under the guidance of Senior Scientist at the conclusion of a project
• Isolate and culture normal tissue cells, cancer cells and other cell types from rodent models of human liver cancers and other liver diseases
• Perform cell-based assays on primary parenchymal and non-parenchymal liver cells, as well as liver cancer cell lines to understand biological/pathological/pharmacological processes-of-interest
• Develop novel cell/tissue culture systems or in vitro assays when needed  

Basic Qualifications 

• Minimum Requirements: Masters with 3+ years or PhD with 0+ years of  experience. 
• Proficiency in common office software (typically Microsoft Word, Excel and PowerPoint)
• Ability to lead and mentor research associates 
• Hands on experience with sterile techniques, maintaining and culturing mammalian cell lines and primary cells
• Creativity and the ability to work with an interdisciplinary team to achieve technical and  corporate milestones
• Exceptional communication, critical thinking and problem-solving skills
• Proficiency in vitro hepatocytes and iPS cell models and assays
• Experience within Vitro and in vivo liver physiology and translational readouts
• Proficiency in culturing and assaying in primary hepatocytes, hepatic-origin cell lines, organoids and similar hepatic cell model systems
• Direct hands-on experience with a variety of cell-based and molecular biology readout technologies, such as flow cytometry immunophenotyping and analysis, FACS (cell sorting), qPCR, ELISA, high-content and confocal imaging.
• Ability to work on weekends when necessary.

Preferred Qualifications 

Prior experience in: 

• Managing junior technicians and/or graduate or undergraduate researchers 
• Experience with Monday.com, Instagantt, and Python 
• Independent planning and execution of complex in vitro experiments 
• Experience with co-culture models or 3D culture systems, MPS (micro physiological system) (3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip) is a plus.
• Performing gene editing experiments in hepatic cell lines and primary hepatocytes from multiple species to assess prime editing and phenotypic responses

We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of  personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for  employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or  veteran status.

Click here to download a PDF of this job description: Scientist I_II -Liver Biologist

About You 

• You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
• You are conscientious and pay almost obsessive attention to detail, as organized documentation is  second nature. 
• You are curious, love learning and are eager to take on hard problems. 
• You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
• You are resourceful and like to work independently but are not shy to ask for advice.
• Experienced bench-level immunologist proficient in the isolation, culture, and functional characterization of primary human immune cells, specifically NK, dendritic cells, macrophages, T cells and B cells
• Highly skilled with immunological techniques (high level of expertise in flow cytometry required, ELISA, cell culture and phenotypic characterization of primary immune cells)

What You’ll Do 

• Keep detailed and organized records of experimental protocols and results 
• Present findings and data analysis in research meetings. 
• Compile and interpret data and prepare presentations for management review 
• Assign tasks to and mentor junior scientists (research associates and research assistants) 
• Develop statement of work (SOW) and standard operating procedures (SOPs) for client contracts
• Present data in client meetings 
• Write and submit final reports and manuscripts under the guidance of Senior Scientist at the conclusion of a project
• Create, maintain, and curate human patient derived cell sample biorepository, associated QC materials/reagents, and protocols for use/application
• Assess the therapeutic potential of candidate drug molecules using in vitro assays of innate and adaptive immune cell function with a focus on adaptive immunology (NK, myeloid cells, B cells and T cells)
• Execute experiments with minimal supervision and delivers comprehensive, high-quality data sets to enable decision-making
• Design, develop and optimize new assays for immune system profiling both independently and in collaboration with a team of other researchers
• Be a source of expertise for cutting edge immunology by keeping up with current literature

Basic Qualifications 

• Minimum Requirements: Masters with 3+ years or PhD with 0+ years of  experience. 
• Proficiency in common office software (typically Microsoft Word, Excel and PowerPoint)
• Ability to lead and mentor research associates 
• Experience with mammalian cell culture 
• Creativity and the ability to work with an interdisciplinary team to achieve technical and  corporate milestones
• Exceptional communication, critical thinking and problem-solving skills 
• Knowledge of human pluripotent stem cell culture, characterization, and QC.
• Experience with ESC/iPSC differentiation protocols, reprogramming techniques, and functional readouts.
• Working knowledge of in vivo application of iPSC-derived cell models
• Direct hands-on experience with a variety of cell-based and molecular biology readout technologies, such as flow cytometry immunophenotyping and analysis, FACS (cell sorting), qPCR, ELISA, high-content and confocal imaging.
• Ability to work on weekends when necessary.

Preferred Qualifications 

Prior experience in: 

• Managing junior technicians and/or graduate or undergraduate researchers 
• Experience with Monday.com, Instagantt, and Python 
• Independent planning and execution of complex in vitro experiments 
• Experience with co-culture models or 3D culture systems, MPS (micro physiological system) (3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip) is a plus.
• High level experience in adaptive immunology (B cells, T cells, antibodies)
• Have previously developed in vitro models of T/B cell activation

We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of  personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for  employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or  veteran status.

Click here to download a PDF of this job description: Scientist I_II- Immunologist (Adaptive Immunity)

About You 

• You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
• You are conscientious and pay almost obsessive attention to detail, as organized documentation is  second nature. 
• You are curious, love learning and are eager to take on hard problems. 
• You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
• You are resourceful and like to work independently but are not shy to ask for advice. 

What You’ll Do 

• Keep detailed and organized records of experimental protocols and results 
• Design, optimize and oversee day to day experiments 
• Present findings and data analysis in research meetings. 
• Compile and interpret data and prepare presentations for management review 
• Assign tasks to and mentor junior scientists (research associates and research assistants) 
• Manage multiple projects (2-4) simultaneously ensuring each project meets required deliverables in  appropriate deadline 
• Develop statement of work (SOW) and standard operating procedures (SOPs) for client contracts
• Present data in client meetings 
• Establish and oversee quality control in all aspects of your team projects 
• Write and submit final reports and manuscripts under the guidance of Senior Scientist at the conclusion of a project
• Develop models of barrier tissues (BBB, Kidney, GI tract)
• Measure efflux/influx transporter activity, tight junction formation, TEER, and transport kinetics 

Basic Qualifications 

• Minimum Requirements: Masters with 3+ years or PhD with 0+ years of  experience. 
• Proficiency in common office software (typically Microsoft Word, Excel and PowerPoint)
• Ability to lead and mentor research associates 
• Experience with mammalian cell culture 
• Creativity and the ability to work with an interdisciplinary team to achieve technical and  corporate milestones
• Exceptional communication, critical thinking and problem-solving skills 
• Knowledge in culturing brain microvascular endothelial cells, astrocytes, pericytes and models of the BBB
• Experience with TEER measurement methodologies
• Experience in transporter activity studies and modulation of transporter activity
• Ability to work on weekends when necessary.

Preferred Qualifications 

Prior experience in: 

• Managing junior technicians and/or graduate or undergraduate researchers 
• Experience with Monday.com, Instagantt, and Python 
• Independent planning and execution of complex in vitro experiments 
• Experience with co-culture models or 3D culture systems, MPS (micro physiological system) (3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip) is a plus.
• Working knowledge of genome editing tools (CRISPR-Cas9, base editing, prime editing) is a plus
• Additional experience in glomerular and proximal tubule biology

We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of  personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for  employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or  veteran status.

Click here to download a PDF of this job description: Scientist I_II- BBB Biologist

About You 

• You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
• You are conscientious and pay almost obsessive attention to detail, as organized documentation is  second nature. 
• You are curious, love learning and are eager to take on hard problems. 
• You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
• You are resourceful and like to work independently but are not shy to ask for advice. 

What You’ll Do 

• Keep detailed and organized records of experimental protocols and results 
• Design, optimize and oversee day to day experiments 
• Present findings and data analysis in research meetings. 
• Compile and interpret data and prepare presentations for management review 
• Assign tasks to and mentor junior scientists (research associates and research assistants) 
• Manage multiple projects (2-4) simultaneously ensuring each project meets required deliverables in  appropriate deadline 
• Develop statement of work (SOW) and standard operating procedures (SOPs) for client contracts
• Present data in client meetings 
• Establish and oversee quality control in all aspects of your team projects 
• Write and submit final reports and manuscripts under the guidance of Senior Scientist at the conclusion of a project
• Create, maintain, and curate human patient derived cell sample biorepository, associated QC materials/reagents, and protocols for use/application
• Contribute to the establishment of protocols for directed differentiation of human pluripotent cells to model a variety of cell types and diseases.
• Support development of disease phenotype-specific molecular and functional assays in relevant cell types differentiated from human pluripotent stem cells (such as enzymatic activity, receptor function, metabolic assays).  

Basic Qualifications 

• Minimum Requirements: Masters with 3+ years or PhD with 0+ years of  experience. 
• Proficiency in common office software (typically Microsoft Word, Excel and PowerPoint)
• Ability to lead and mentor research associates 
• Experience with mammalian cell culture 
• Creativity and the ability to work with an interdisciplinary team to achieve technical and  corporate milestones
• Exceptional communication, critical thinking and problem-solving skills 
• Knowledge of human pluripotent stem cell culture, characterization, and QC.
• Experience with ESC/iPSC differentiation protocols, reprogramming techniques, and functional readouts.
• Working knowledge of in vivo application of iPSC-derived cell models
• Direct hands-on experience with a variety of cell-based and molecular biology readout technologies, such as flow cytometry immunophenotyping and analysis, FACS (cell sorting), qPCR, ELISA, high-content and confocal imaging.
• Ability to work on weekends when necessary.

Preferred Qualifications 

Prior experience in: 

• Managing junior technicians and/or graduate or undergraduate researchers 
• Experience with Monday.com, Instagantt, and Python 
• Independent planning and execution of complex in vitro experiments 
• Experience with co-culture models or 3D culture systems, MPS (micro physiological system) (3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip) is a plus.
• Working knowledge of genome editing tools (CRISPR-Cas9, base editing, prime editing) is a plus

We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of  personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for  employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or  veteran status.

Click here to download a PDF of this job description: Scientist I_II- iPSC Biologist

Job Title: Automation Engineer

Hesperos is building an in-house automation team for the production of our biological testing platforms. We are looking for an experienced engineer with a background in automation and general mechatronic design.

Hesperos, Inc. is accelerating drug discovery by providing safety and efficacy testing of chemicals and novel therapeutics for the pharmaceutical, cosmetic, and food industries using its patented, Human-on-a-Chip platform. Bringing together biologists, surface chemists, and engineers, our team is producing some of the world’s most advanced organs-on-a-chip platforms. From gene expression to electrophysiology, we recreate key components of organs in an interconnected, functional system. Chemically patterned microchips enable real-time, non-invasive monitoring of organ activity where we use sophisticated measurement techniques to detect minute changes. This breakthrough technology enables unprecedented visibility into specific disease states and how the human body will respond to treatment - something that previously required costly animal testing and human trials to determine. As a functional, interconnected, human surrogate, Hesperos’ Human-on-a-Chip provides preclinical insight into the efficacy and toxicity of novel therapeutics.

This role will be self-driven and requires an applicant who takes joy in implementing and learning about automation technology.

In this role you will be responsible for: 

• Designing and implementing new automation platforms to improve the throughput and quality of our production processes
• Assembly and qualification of custom automation platforms for use by operators
• Integration of automation platforms with OEM lab equipment
• Maintaining and updating existing automation platforms
• Working cross-functionally with our R&D team in order to generate requirements that solve real problems

Applicant must have the following qualifications:

• 3+ years of mechanical design experience with a 3D parametric CAD platform
• Intimate familiarity with common mechanical components including:
  • Servo and stepper motors
  • Pneumatic actuators and cylinders
  • Rotary and linear motion components
  • Extruded aluminum framing systems
• Advanced understanding of part fixturing and handling
• Working knowledge of common electrical components and electrical systems
• Working knowledge of software concepts including experience with programmable logic controllers (PLCs)

Ideally, the applicant will also have the following qualifications:

• Experience with common fabrication methods including 3-axis milling and turning
• Experience with embedded electrical systems including printed circuit board (PCB) design and embedded software development
• Experience with industrial robotics

We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or veteran status.

How to Apply:

Send your resume and any relevant documents to Careers@hesperosinc.com

Visit our website (hesperosinc.com) to learn more about the company and leadership team. 

We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of  personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for  employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or  veteran status.

Click here to download a PDF of this job description: Automation Engineer

Job Title: Research Associate Level I/II

About Us: Hesperos, Inc. brings together biologists, surface chemists, and engineers to produce some of the worlds most advanced organs-on-chip platforms. From gene expression to electrophysiology, our biologists recreate key components of various organs and combine them in multi-organ functional systems. Chemically patterned microchips are engineered to enable real-time monitoring of organ activity. Finally, our engineers utilize sophisticated measurement techniques to detect and quantify minute changes.  The result of this collaboration is an ability to study therapeutics in a unique way which we are using to predict clinical outcomes.

About You

• You are a rigorous experimentalist who takes pride in your ability to execute at the bench.
• You are conscientious and pay almost obsessive attention to detail, as organized documentation is second nature.
• You are curious, love learning and are eager to take on hard problems.
• You thrive in a fast-paced environment and enjoy pushing the edge of what is possible.
• You are resourceful and like to work independently but are not shy to ask for advice.
• You are able to troubleshoot and precisely communicate potential issues with daily tasks.

What You’ll Do

• Collaborate and communicate across a diverse interdisciplinary research team.
• Work with scientists to collect and interpret data from proprietary Hesperos’ developed software and hardware for multiple drug discovery efforts.
• Ensure that all safety guidelines are followed strictly and maintain a clean and orderly environment.
• Keep detailed and organized records of experimental protocols and results.
• Execution of experiments according to Hesperos SOPs.

Basic Qualifications

• A Bachelors or Masters degree in cell biology, molecular biology, biomedical sciences or related field
• 0-4 years of independent and/or industry laboratory research experience
• Ability to independently execute experiments and perform data analysis (excel, prism etc.)
• Proficiency in common office software (typically Microsoft Word, Excel and PowerPoint)
• Strong organizational and documenting skills with keen attention to detail
• Creativity and the ability to work with an interdisciplinary team to achieve technical and corporate milestones.
• Exceptional communication, critical thinking and problem-solving skills

Preferred Qualifications

• Proficiency in in vitro cell culture of mammalian cells
• Experience in modern cell and molecular biology techniques (RT-PCR, flow cytometry, immunocytochemistry)
• Knowledge of cardiac function, liver function or neuromuscular physiology is a plus.

We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or veteran status.

Click here to download a PDF of this job description: Research Associate I_II

About Us: Hesperos, Inc. brings together biologists, surface chemists, and engineers to produce some of the worlds most advanced organs-on-chip platforms. From gene expression to electrophysiology, our biologists recreate key components of various organs and combine them in multi-organ functional systems. Chemically patterned microchips are engineered to enable real-time monitoring of organ activity. Finally, our engineers utilize sophisticated measurement techniques to detect and quantify minute changes.  The result of this collaboration is an ability to study therapeutics in a unique way which we are using to predict clinical outcomes.